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Your protocol planning should account for this shift and set appropriate expectations for the second half of treatment

Hcy must be recycled: it is a toxic metabolite that inhibits the methylation process and can also inactivate some proteins via homocysteinilation, which leads to structural modifications

Obesity elevates the risk of asthma and obese patients tend to have uncontrolled symptoms, more frequent and severe exacerbations, as well as a worse response to ICS